Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries

Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries

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The plasticizer bisphenol A, a tashi bharucha typical endocrine disrupting chemical, is widely present in the environment.Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility.However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures have not been fully determined.In this study, we explored the transcriptomic profiles of female zebrafish ovaries.The transcriptomic data revealed that mitochondrial NADH dehydrogenase (mt-Nd) genes were significantly decreased in the bisphenol A-exposed group, while the co-administration of tea polyphenols remarkably elevated the jolly joes grape candy expression of mt-Nd genes.

To further explore the expression pattern of the mt-Nd, we analyzed the expression of six mt-Nd genes on different days by qRT-PCR in control, bisphenol A-exposed, and bisphenol A-tea polyphenols ovaries.Here, we found that 0.1 mg/L bisphenol A exposure adversely affects the mitochondrial respiratory chain in ovaries and may lead to reproductive disorders.Finally, our study demonstrated that tea polyphenols play a protective role in ovarian mitochondrial dysfunction in low-concentration bisphenol A-exposed female zebrafish.